RETURNYonago Acta medica 1991;34:175-184
Suppression of Experimental Allergic Neuritis by Bactobolin
Hiroshi Kagimoto and Shigeru Araga
Division of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago 683, Japan
Experimental allergic neuritis (EAN) was induced in Lewis rats, and these rats were injected with bactobolin into the peritoneal cavity for 13 days from the day after inoculation with a dose of 0.5 mg/kg/day (group A) and 1.0 mg/kg/day (group B). Bactobolin was able to delay the onset of EAN, but not prevent the development of EAN. On day 10 of bactobolin administration, the percentages of W3/25 positive T cells in the peripheral blood of groups A and B were higher than those of the control rats (group C), matching the dosage of bactobolin. The percentages of OX-8 positive T cells in the peripheral blood and T-cell subsets (W3/25 and OX-8) in the spleen and lymph nodes were not significantly different in the 3 groups. Our results suggest that bactobolin delayed the onset of EAN by increasing the number of W3/25 positive suppressor T cells in the peripheral blood.
Key words: bactobolin; experimental allergic neuritis; OX-8 positive T cells; T-cell subsets; W3/25 positive T cells