Yonago Acta medica 2006;49:49-58
Relationship between an Angiotensinogen Gene
Polymorphism (M235T) and Serum Lipids: A Cross-Sectional Study among Japanese Workers
Akihiko Kaetsu, Takuji Kishimoto, Yoneatsu Osaki, Mikizoh Okamoto and Yoichi Kurozawa*
Division of Environmental and Preventive Medicine and *Division of Health Administration and Promotion, Department of Social Medicine, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8503 Japan
Angiotensinogen (AGT) is a component of the renin-angiotensin system, which plays a central role in blood pressure regulation. Although it is controversial, the association between AGT gene polymorphisms and hypertension, and coronary heart disease is suspected. In a case-control study on the metabolic syndrome, an association between AGT M235T polymorphism and serum total cholesterol (TC) level was demonstrated by Thomas et al. (2001). To reconfirm this relationship, a cross-sectional study among Japanese workers with 876 dyslipidemia and 1,158 non-dyslipidemia subjects was carried out. To evaluate the AGT M235T polymorphism, a PCR-mutant allele specific amplification (MASA) method was employed. No significant difference in the distribution of genetic variance was observed between the two groups. Although it was not significant, the T allele correlating to the lower TC of the present study occurred in a reversed manner to the previous report. In our results, no significant association between AGT M235T and TC was observed.
Key words: angiotensinogen; polymorphism (genetics); cholesterol; cross-sectional study; Japanese workers
