<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.0//EN" "http://www.w3.org/TR/REC-html40/strict.dtd"> <HTML> <HEAD> <META name="generator" content="Adobe InDesign HTML Export Plug-in"> <META http-equiv="Content-Type" content="text/html; charset=iso-8859-1"> <META http-equiv="Content-Style-Type" content="text/css"> <TITLE>yam49_049-058.html</TITLE> <STYLE type="text/css"> <!-- #layer1 {position: absolute; top: 9px; left: 18px; padding: 0px; margin: 0px; z-index: 1} .dynamic-style-1 {text-align: left} .dynamic-style-2 {font-family: 'Times'; font-size: 14px; line-height: 14px; color: #000000; font-weight: bold} .dynamic-style-4 {margin-top: 11px; margin-bottom: 8px; text-align: left} .dynamic-style-5 {font-family: 'Times'; font-size: 17px; line-height: 18px; color: #000080; font-weight: bold} .dynamic-style-6 {margin-bottom: 8px; text-align: left} .dynamic-style-7 {font-family: 'Times'; font-size: 16px; line-height: 18px; color: #000000; font-weight: bold} .dynamic-style-8 {margin-bottom: 14px; text-align: left} .dynamic-style-9 {font-family: 'Times'; font-size: 15px; line-height: 16px; color: #000000; font-style: italic} .dynamic-style-10 {font-family: 'Times'; font-size: 15px; line-height: 17px; color: #000000} .dynamic-style-11 {margin-bottom: 17px; text-align: left} .dynamic-style-12 {font-family: 'Times'; font-size: 14px; line-height: 14px; color: #000000; font-weight: bold} --> </STYLE> </HEAD> <BODY bgcolor="#F0FFFF"> <DIV id="layer1"> <DIV class="dynamic-style-1"> <SPAN class="dynamic-style-2">Yonago Acta medica 2006;49:49-58</SPAN> </DIV> <DIV class="dynamic-style-4"> <SPAN class="dynamic-style-5">Relationship between an Angiotensinogen Gene Polymorphism (M235T) and Serum Lipids: A Cross-Sectional Study among Japanese Workers <BR></SPAN> </DIV> <DIV class="dynamic-style-6"> <SPAN class="dynamic-style-7">Akihiko Kaetsu, Takuji Kishimoto, Yoneatsu Osaki, Mikizoh Okamoto and Yoichi Kurozawa* <BR></SPAN> </DIV> <DIV class="dynamic-style-8"> <SPAN class="dynamic-style-9">Division of Environmental and Preventive Medicine and *Division of Health Administration and Promotion, Department of Social Medicine, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8503 Japan<BR></SPAN> </DIV> <DIV class="dynamic-style-6"> <SPAN class="dynamic-style-10">Angiotensinogen (AGT) is a component of the renin-angiotensin system, which plays a central role in blood pressure regulation. Although it is controversial, the association between AGT gene polymorphisms and hypertension, and coronary heart disease is suspected. In a case-control study on the metabolic syndrome, an association between AGT M235T polymorphism and serum total cholesterol (TC) level was demonstrated by Thomas et al. (2001). To reconfirm this relationship, a cross-sectional study among Japanese workers with 876 dyslipidemia and 1,158 non-dyslipidemia subjects was carried out. To evaluate the AGT M235T polymorphism, a PCR-mutant allele specific amplification (MASA) method was employed. No significant difference in the distribution of genetic variance was observed between the two groups. Although it was not significant, the T allele correlating to the lower TC of the present study occurred in a reversed manner to the previous report. In our results, no significant association between AGT M235T and TC was observed. <BR></SPAN> </DIV> <DIV class="dynamic-style-11"> <SPAN class="dynamic-style-12">Key words: angiotensinogen; polymorphism (genetics); cholesterol; cross-sectional study; Japanese workers<BR></SPAN> </DIV> <DIV class="dynamic-style-6"> <SPAN class="dynamic-style-10"> <IMG SRC="../pdficonsmall.gif" ALIGN="MIDDLE" BORDER="0" HSPACE="10" X-SAS-IseImageWidth X-SAS-UseImageHeight> <A HREF="49_049-058.pdf ">Full text with/without table(s) and graphic(s) in PDF (108 k)</A> <BR> <BR> <IMG SRC="../../backIcon.gif" ALIGN="middle" hspace="10"> <A HREF="49-1contents.html"> RETURN</A><BR><BR></SPAN> </DIV> </DIV> </BODY> </HTML>