Yonago Acta medica 2004;47:91-96
Myeloma-Associated Fanconi Syndrome Due to λ-Light Chain Crystal Deposition
Keitaro Noguchi, Chishio Munemura, Satoko Maeda, Satoru Yamamoto, Yoshikazu Murawaki, Toshiyuki Kaidoh* and Shinichi Morino†
Division of Medicine and Clinical Science, Department of Multidisciplinary Internal Medicine, *Division of Morphological Analysis, Department of Functional, Morphological and Regulation Science, School of Medicine and †Laboratory of Electron Microscopy, Tottori University Faculty of Medicine, Yonago 683-8503 Japan
Multiple myeloma is uncommonly complicated with Fanconi syndrome, due to the deposition of light chains in renal tubular epithelial cells. A 76-year-old man with λ-Bence Jones type multiple myeloma had adult Fanconi syndrome. Electron microscopy showed that rhomboid, high-density substances of various sizes, were accumulated in the proximal tubular epithelial cells on renal biopsy. Immunoelectron microscopy demon-strated that these crystals were λ-light chains. The deposition of κ-light chain in patients with myeloma-associated Fanconi syndrome has been known. This is the 1st report showing the deposition of λ-light chain in renal proximal tubular epithelial cells.
Key words: Fanconi syndrome; immunoelectron microscopy; multiple myeloma
