Yonago Acta medica 2004;47:37–44
Fast and Slow Oscillation Electrooculography in Harada Disease
Akihiko Tamai*, Junji Hamamoto#, Jiro Hasegawa, Takashi Baba, Shiro Hatta and Yuji Sasaki
Division of Ophthalmology and Visual Science, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8504, *Clinic of Ophthalmology, Hino Hospital Association Hino Hospital, Hino 689-4504 and #Clinic of Ophthalmology, Matsue Municipal Hospital, Matsue 690-8509 Japan
We assessed clinical utility of fast and slow oscillations (FO and SO) of the electrooculogram (EOG) in Harada disease. In 12 eyes of 4 female and 2 male subject patients aged 18 to 77 years (average: 41.8 years), FO and SO were recorded using an automated electrooculograph, the Nidek EOG-2, in the acute period before treatment and in the
remission period under corticosteroid therapy. FO parameters, namely the RfFO [the average ratio in percentage of the maximum amplitude in the dark period (AD)/the minimum amplitude in the light period (AL) during FO measurement] and the dfFO (the average difference in µV between AD and AL) were evaluated. The L/DSO (the light peak/dark trough ratio of the SO) was calculated as an SO parameter. The RfFO, dfFO and L/DSO showed low values in 7 (58.3%), 10 (83.3%) and 8 (66.7%) out of all 12 eyes in the acute
period, respectively. In the remission period, values in the normal range were obtained in 12 (100%), 11 (91.7%) and 8 (66.7%) out of 12 eyes in the RfFO, dfFO and L/DSO, respectively. In mutual relation to each RfFO, dfFO and L/DSO in the acute and remission periods, all 12 eyes showed recovery values both in the RfFO and
dfFO in the remission stage after systemic administration of corticosteroids, but 4 out of 12 eyes (33.3%) showed no recovery in the L/DSO. The FO may therefore well reflect the affected or ameliorated conditions in the outer layers of the retina and the choroid in Harada disease, in contrast to the SO. However, further observations are requested in more Harada disease patients.
Key words: acute and remission periods; electrooculogram; fast oscillation; Harada disease; slow oscillation
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