Four cases of multiple myeloma presenting symptoms in the oral and maxillofacial region are reported. The main complaints in 2 patients were macroglossia and dysphagia. We doubted these cases were amyloidosis, but examinations performed for possible amyloidosis led us to a diagnosis of multiple myeloma. The other 2 patients presented signs in the mandible. One of them had a mass-type lesion in the gingiva which upon X-ray revealed an osteolytic lesion in the mandible and multiple "punched-out" osteolytic lesions in the cranial bones. The other showed only a diffuse non-homogeneous radiolucent lesion and dental ankylosis. Medical history and biochemical and hematologic findings would be helpful in diagnosing multiple myeloma. Here, we report our summarization of these 4 cases.