Yonago Acta medica 2002;45:117-120
A Case of Malignant Gastrointestinal Stromal Tumor of the Transverse Colon: Evaluation of Proliferation Activity
Satoru Kase, Hironobu Adachi, Mitsuhiko Osaki, Kohei Shomori, Soichiro Honjo, Eizo Goto, Hideki Yamashita, Hiroki Kawaguchi* and Hisao Ito
Division of Organ Pathology, Department of Microbiology and Pathology, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8503 and *Clinic of Surgery, National Yonago Hospital, Yonago 683-8518 Japan
Here, we report a colonic gastrointestinal stromal tumor (GIST) in a middle-aged man above 40. A histologically similar second tumor was detected 2 years after initial surgery. The primary GIST, measuring 5.5 ¥ 6.0 cm, consisted of spindle tumor cells with a higher number of mitoses and Ki67 labeling index (about 20%) than those of the second tumor, implying a de novo GIST. These markers might be useful in evaluating malignant potential, as well as to differentiate between a de novo and a recurrent tumor in the colonic GIST.
Key words: colon; gastrointestinal stromal tumor; Ki67; mitosis
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