Yonago Acta medica 2000;43:81–86
Successful Management of Humoral Hypercalcemia of Malignancy in A Patient with Ovarian Cancer
Fuminori Taniguchi, Junzo Kigawa, Riko Kitazawa* and Naoki Terakawa
Department of Obstetrics and Gynecology, Faculty of Medicine, Tottori University, Yonago 683-0826 and *Second Department of Pathology, Kobe University School of Medicine, Kobe 650-0017, Japan
We present here successful treatment with bisphosphonate pamidronate of a 54-year-old patient with advanced ovarian cancer and humoral hypercalcemia of malignancy, followed by cytoreductive surgery and postoperative chemotherapy. Concentration of serum calcium increased to 16.8 mg/dL and parathyroid hormone-related protein (PTHrP)-intact was remarkably elevated. Interestingly, the 1,25-dihydroxyvitamin D (1,25-DHD) was high in this case. Treatment with bisphosphonate pamidronate was effective for the improvement of hypercalcemia so that she could undergo optimal surgery followed by postoperative chemotherapy. The histochemical examination of PTHrP using anti-human monoclonal antibody showed positive staining in the cancer cells of the ovary.
Key words: bisphosphonate pamidronate; humoral hypercalcemia of malignancy; parathyroid hormone-related protein
Full text with/without table(s) & graphic(s) in PDF (232 k)