Yonago Acta medica 1997;40:133–136
Regulation of the Expression of Epidermal Growth Factor
Receptor mRNA with Thyroid Hormone L-3,5,3'-Triiodothyronine in Rat Hepatoma Cells
Yukio Satoh and Takeshi Sairenji
Department of Biosignaling, Faculty of Medicine, Tottori University, Yonago 683 Japan
The expression of epidermal growth factor (EGF) receptor mRNA
was examined using thyroid hormone L-3,5,3'-triiodothyronine (T3) by
Northern blot analysis in rat hepatoma cells. The expression of
full-length, but not truncated receptor mRNA was enhanced and
destabilized with T3. These results suggest that T3 induces not only
the expression of full-length EGF receptor mRNA but also accelerates
their rate of turnover. The 3' terminal region of full-length EGF
receptor mRNA may have a role in the destabilization of EGF receptor
mRNA by T3, because truncated EGF receptor mRNA lacks only the 3'
terminal region of full-length EGF receptor mRNA.
Key words: EGF receptor; EGF receptor mRNA; mRNA stability;
regulation of gene expression; thyroid hormone
