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Penicillin Resistant of Streptococcus pneumoniae Clinically Isolated in Yonago Area during 1986-1994
Seiji Yamasaki, Yuji Sugimoto, Hidemi Teramoto, Hiroki Chikumi, Tatsuya Konishi, Shinji Hori, Yukio Matsumoto and Takao Sasaki
Third Department of Internal Medicine, Faculty of Medicine, Tottori University, Yonago 683, Japan
One-hundred-thirty Streptococcus pneumoniae (S. pneumoniae) isolates were recovered from patients in 1986-1994. Twenty-eight (21.5%) had a minimum inhibitory concentration (MIC) to penicillin G (PCG) of ≥ 0.1 µg/mL but none had ≥ 3.13 µg/mL. Seventeen percent had an MIC to cefotiam of ≥ 0.78 µg/mL. Thirty-two point five percent had an MIC to erythromicine ≥ 0.39 µg/mL. Seventy-three percent had an MIC to minocycline ≥ 0.78 µg/mL. The percentages of the isolates that were relatively resistant to PCG (MICs, 0.1-1.56 µg/mL) were 8% in 1986, 12.5% in 1988, 60% in 1992 and 50% in 1994, respectively. The increasing number of S. pneumoniae isolates resistant to penicillin and other antimicrobials in Yonago area supports the need to monitor for changes in the susceptibilities of antimicrobial agents.
Key words: antimicrobial susceptibility; penicillin resistance; respiratory disease; Streptococcus pneumoniae