RETURNEffects of Lecithin-Bound Iodine (Jolethin) on the Oscillatory Potential in the Normal Rabbit Electroretinogram
Akihiko Tamai, Kyutaro Ito, Masao Nagata, Hiroyuki Sugimori, Junji Hamamoto, Hiroshi Nakao, Norio Miki, Nanae Kunito, Akira Setogawa and Yutaka Takagi
Department of Ophthalmology, Faculty of Medicine, Tottori University, Yonago 683, Japan
The effects of oral administration of lecithin-bound iodine (Jolethin) on the oscillatory potential in the normal electroretinogram were studied in adult albino rabbits. The experimental animals were divided into 4 groups of 5 rabbits each. One group served as the control. The rabbits in the A, B and C test groups were orally administered lecithin-bound iodine dissolved in water (colloid solution) through a stomach tube. Iodine dose levels were 2 µg, 6 µg and 18 µg/kg of body weight per day of Jolethin powder, respectively. The application was carried out for 3 months. The control rabbits were orally given only water instead of Jolethin. Significant increases in the amplitudes of the oscillatory potential (O1, O2, O3, N1, N2) and significant shortenings in their peak latencies were detected in the 3 test groups. Especially, this tendency was remarkable in the highly-dosed C group. As a result, it was concluded that oral administration of Jolethin lasted over the relatively long term is effective on the facilitation of the oscillatory potential generated by the neural feedback circuits. This facilitation is highly suggestive of accomplishment via the thyroid gland at the level of the inner nuclear layer of the retina in adult albino rabbits.
Key words: lecithin-bound iodine; normal rabbit electroretinogram; oral administration; oscillatory potential; retinal metabolism