RETURNYonago Acta medica 1992;35:45–54
Effects of Indeloxazine Hydrochloride on Brainstem Auditory Evoked Potentials
Ryuzo Kawahara, Toru Kuwai, Susumu Takada, Yuzo Tanaka and Hidebumi Hazama
Department of Neuro-Psychiatry, Faculty of Medicine, Tottori University, Yonago 683, Japan
Eighteen patients with dementia were treated with indeloxazine hydrochloride (IXZ) for 2 months and their brainstem auditory evoked potentials (BAEPs) were recorded before and after the administration of IXZ. The patients were divided into 2 groups: The 1st group consisted of 11 patients with multiinfarct dementia (MID group), while the 2nd group consisted of 5 patients with dementia of the Alzheimer type and 2 patients with Parkinson's disease (degenerative group). The results obtained were as follows: i) Dementia in the patients did not improve with the administration of IXZ for 2 months. With respect to insomnia, restlessness and excitation, however, 5 out of 10 patients (50%) showed significant improvement, 4 patients (40%) showed moderate improvement and 1 patient (10%) remained unchanged. ii) The peak latencies of each wave were prolonged after IXZ administration. In particular, the peak latencies in Wave-III and V were prolonged significantly in the MID group (P < 0.05). Interpeak latencies in Wave III–V of the MID group were also prolonged significantly (P < 0.05). In contrast, interpeak latencies in Wave III–V of the degenerative group were reduced significantly. iii) The peak latencies and the severity of dementia showed a positive correlation. In particular, the peak latency of Wave-I in severe dementia was prolonged more significantly than in moderate dementia (P < 0.05).
Key words: brainstem auditory evoked potentials; dementia; indeloxazine hydrochloride