RETURNYonago Acta medica 1992;35:217–220
The Clinical Benefits of E-4031, a Novel Class III Antiarrhythmic Drug, on Myocardial Contractility
Takahiro Nawada, Tetsuya Doi, Ichiro Hisatome, Yasunori Tanaka, Hiroshi Kotake and Hiroto Mashiba
First Department of Internal Medicine, Faculty of Medicine, Tottori University, Yonago 683, Japan
Many antiarrhythmic drugs that belong to classes I and IV of the Vaughan Williams classification have been known to cause myocardial depression. In this study, we observed the inotropic effect of E-4031, a novel class III anti-arrhythmic drug, compared with that of class I and class IV antiarrhythmic drugs. The study revealed that E-4031 does not have a significant inotropic effect. With clinical efficacy for reentrant tachycardia, E-4031 was considered to be a suitable antiarrhythmic agent for patients with myocardial failure.
Key words: E-4031; antiarrhythmic drug; myocardial contractility