RETURNYonago Acta medica 1992;35;127–132
S100 Protein-Positive T-Cell Lymphoma: Report of Three Cases
Makoto Motoi, Yukisato Kitamura, Masako Kato, Hideo Akiyoshi, Keiichi Ichihara, Shu Nakamoto*, Tadashi Yoshino†, Kiyoshi Takahashi† and Tadaatsu Akagi†
Second Department of Pathology, Faculty of Medicine, Tottori University, Yonago 683, *Department of Pathology, Tottori Prefecture Central Hospital, Tottori 680 and †Second Department of Pathology, Okayama University Medical School, Okayama 700, Japan
The presence of S100 protein-positive (S100+) lymphocytes in the peripheral T-lymhocytes and lymphoreticular tissues is well known. We have attempted to search retrospectively for a neoplastic counterpart of S100+ T-lymphocytes through reviewing a total number of 500 cases of distinct non-Hodgkin’s lymphomas by an immunohistochemical method. As the result, three cases of S100+ lymphomas were found. These three lymphomas were of variable histology, but the immunological characterization was identical, revealing T-cell markers and the presence of S100 protein.
Key words: immunohistochemistry; S100 protein; T-cell malignant lymphoma