Yonago Acta medica 1991;34:113-118

Behavior of Granulocyte-Colony Stimulating Factor (G-CSF) in Pleural Effusions in a Case of Successful Adoptive Immunotherapy

Yutaka Hirota, Takahiko Tanigawa*, Yoshinori Tanaka* and Tohru Mori

Second Department of Surgery and *Department of Bacteriology, Faculty of Medicine, Tottori University, Yonago 683, Japan

We have detected granulocyte-colony stimulating factor (G-CSF) in pleural effusions due to the metastasis of breast cancer which could be controlled by the adoptive transfer of recombinant interleukin 2 (rIL2)-activated pleural-effusion lymphocytes. The G-CSF level was high prior to the therapy, but gradually decreased as lymphocytes were repetitively administered. The level increased 7 days after the 6th administration when the patient complained of a chest pain followed by a prominent infiltration of neutrophils to pleural effusions, and by leukocytosis. All bacterial tests were negative. There was no retention of the effusions after the 7th administration. Cytotoxic T lymphocytes have been suggested as initiating this course of response, and the collaboration of neutrophils is believed to contribute to a more intensive anti-tumor effect.

Key words: granulocyte colony stimulating factor; pleural effusion; immunotherapy

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