RETURNYonago Acta medica 1991;34:105-112
Cytotoxicity of Mouse Macrophage Cell Line, A640-BB-2, against Newborn Larvae of Trichinella spiralis
Soji Fukumoto, Takahiko Tanigawa*, Seiichi Yazaki and Yoshinori Tanaka*
Department of Medical Zoology and *Department of Bacteriology, Tottori University, Yonago 683, Japan
The mouse macrophage cell line A640-BB-2 was cytotoxic against newborn larvae (NBL) of Trichinella spiralis after activation by lipopolysaccharide (LPS). Activated macrophages developed ridge-like processes and spread more extensively on culture substrates than untreated control cells. NBL that were cultured with activated, LPS-stimulated macrophages for 72 h became inactive or were killed. These results indicate that activated macrophages may play an important role in defence against infection with Trichinella spiralis.
Key words: cytotoxicity; macrophage cell line; Trichinella spiralis